Whether C-reactive protein 18 is serious or not needs to be evaluated comprehensively according to the specific condition. C-reactive protein reference value <10mg/L , 18mg / L over the reference value, suggesting the presence of certain diseases. C-reactive protein is an extremely sensitive indicator of acute phase, the clinical significance of C-reactive protein, increased in septic infections, myocardial infarction, major surgery, burns, acute rejection of organ transplantation, malignant tumors, connective tissue disease, etc.; identification of bacterial and non-bacterial infections, the former increased, identification of rheumatic fever in the active phase and the stable phase, increased in the active phase, stable phase when it is not increased, and so on. When C-reactive protein increases, you should go to the hospital in time, improve the relevant examination, find the cause of C-reactive protein increase, targeted treatment to improve the quality of life.