Seronegative spondyloarthropathies are also known as spondyloarthritis, and it is recommended that patients with spondyloarthritis visit the rheumatology department in a timely manner, and can be treated with medication under the guidance of a doctor. Spondyloarthritis, a group of diseases mainly involving the spine and peripheral joints, includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, inflammatory bowel disease arthritis, and many other diseases. These diseases can be treated with medications such as NSAIDs, anti-rheumatic drugs, and biologics, with specific treatment options varying depending on the specific type of disease, condition, and individual constitution of the patient. Non-steroidal anti-inflammatory drugs such as celecoxib can relieve pain and other symptoms, while anti-rheumatic drugs such as sulfasalazine and biologics such as stavudine can control the disease. The prognosis for patients with spondyloarthritis varies greatly depending on their specific condition, but the prognosis is generally better if the condition is well controlled after active treatment. It is recommended that patients diagnosed with spondyloarthritis go to the rheumatology and immunology department of a regular hospital for active treatment.