Symptoms of third-stage syphilis in women are more complicated, and there can be multi-organ involvement, such as the skin, mucous membranes, bones and joints, as well as all internal organs and the nervous system can be damaged. At this time, although there are fewer syphilis spirochetes in the body, they are more powerful in destroying tissues, often causing tissue defects and organ destruction. The first manifestation of syphilis is a syphilitic rash and gumma, which are copper-colored nodules on the head, shoulders, back, and extensor sides of the limbs. In the case of syphilis, the surface of the nodules may break down and a syphilitic substance may flow out. In some cases, the disease invades the heart, leading to syphilitic aortitis, syphilitic aortic valve insufficiency, and syphilitic aortic aneurysm, and in some cases it invades the nerves, leading to symptoms of neurosyphilis.