Total bilirubin of 25.07μmol/L is high, but not serious, if it is physiological high, no treatment is needed, if it is pathologic, such as acute hepatitis, cirrhosis and so on, treatment is needed. 1. Physiological high: such as the transient high caused by drinking a lot of alcohol, strenuous exercise, through rest, abstinence from alcohol, can be restored to normal, do not need treatment. 2. Pathological high: such as acute hepatitis, cirrhosis, cholecystitis, cholelithiasis, pancreatic head cancer and other diseases caused by high total bilirubin, which should be highly attention, need to give standardized treatment to avoid serious condition. When the total bilirubin is high, it is recommended that the patient should consult a doctor in time to find out the cause of the disease and be treated under the guidance of the doctor, so as to avoid delaying the condition.