Colchicine cannot be taken for renal insufficiency, when renal insufficiency exists, it must be used carefully under the guidance of a specialist. Colchicine is mainly used for the treatment of acute attacks of gouty arthritis and the prevention of acute attacks of recurrent gouty arthritis. Adverse effects of colchicine have a significant correlation with the size of the dosage of the drug, and the common adverse effects include gastrointestinal symptoms, such as abdominal pain, diarrhea, vomiting, etc.; muscle, peripheral neuropathy, such as proximal muscle weakness and increased serum creatine phosphokinase, etc.; myelosuppression, such as the appearance of thrombocytopenia, neutrophils, or even aplastic anemia, etc.; and very rarely seen shock, etc.. It should be noted that colchicine is contraindicated in people who are allergic to colchicine drug components, people with low bone marrow hyperplasia, people with renal insufficiency and hepatic insufficiency, pregnant women and lactating women. During the administration of the drug, it is necessary to monitor blood, liver and kidney function and other indicators. If patients need to use colchicine, it is recommended to use the drug under the guidance of a doctor, and not blindly self-medication, in order to avoid adverse effects.