Non-invasive does not have to be done, it needs to be done when indicated and under the supervision of a doctor. Non-invasive refers to non-invasive prenatal testing technology (NIPT), which is a mid-pregnancy screening test to detect the risk of chromosomal disorders occurring in the fetus, and is suitable for secondary screening of high-risk groups, such as Down’s syndrome screening for critical risk, and the risk of not accepting amniocentesis for pregnant women of advanced age. The test should be performed after clear indications under the supervision of a doctor, and it is recommended that pregnant women with indications must undergo the test to ensure the quality of pregnancy. However, when the non-invasive is a positive result, it can only indicate an increased risk of fetal disease, and further prenatal diagnosis is needed to clarify. NIPT is not suitable for pregnant women with special conditions such as chromosomal disorders or abnormalities in fetal structural development, and prenatal counseling and prenatal diagnostic tests should be performed according to the doctor’s instructions.