The skin of membranous nephropathy usually has no special manifestation, if the patient is combined with renal insufficiency, there may be dry skin, itchy skin and other features. Membranous nephropathy usually shows proteinuria, edema, hyperlipidemia, hypoproteinemia and other symptoms, usually no obvious features on the skin. If the patient’s disease is poorly controlled and combined with decreased glomerular filtration rate, it may show dryness and itching on the skin. This is due to the fact that the retention of nitrogen metabolites in patients with membranous nephropathy can cause skin irritation, sebaceous gland atrophy, and renal insufficiency with phosphorus excretion obstacle, thus inducing generalized dry and flaky skin and generalized itching. When itchy and dry skin occurs, patients need to pay attention to skin moisturizing, warmth and low phosphorus diet in daily life, and at the same time, they should pay attention to reduce the frequency of bathing and do not wipe the skin with force. It is recommended that patients with membranous nephropathy should go to regular hospitals in time and under the guidance of doctors for standardized treatment to avoid aggravation of the condition.