The symptoms of numbness of legs and hands should be analyzed in the light of the patient’s underlying disease and the form of onset of the disease. If the numbness of the hands and feet is unilateral, it should be considered to be caused by cerebrovascular disease, such as cerebral infarction or cerebral hemorrhage, when the sensory nerves are damaged, the patient will be manifested as numbness of the affected side, the opposite side of the limb sensation and pain and other symptoms. If the numbness of legs and hands is chronic, the slow appearance of unilateral numbness of the limbs should be considered to be caused by intracranial tumors and intracranial space occupation. If the numbness of legs and hands is symmetrical, it should be considered that it is caused by peripheral neuropathy or peripheral neuritis, such as diabetic peripheral neuropathy or alcoholic peripheral neuropathy, and it should also be considered that cervical and lumbar vertebrae problems, when the compression of the nerve root, the patient will also have numbness of legs and hands.