Endplate inflammation is an aseptic inflammation of the endplate cartilage of the vertebral body and is a self-limiting disease that usually heals spontaneously in 2-3 weeks. Endplate inflammation is mainly due to degenerative changes in the lumbar intervertebral discs or inflammatory reactions caused by damage to the endplate cartilage due to external forces. Patients mainly present with lumbar pain, which is significantly increased by coughing or shock and affects spinal movement. In the acute stage of endplate inflammation, patients are advised to rest in bed to reduce the pressure on the intervertebral discs, and most patients can get better on their own in 2-3 weeks. If the patient’s pain and restricted movement are more severe, bed rest can be combined with oral non-steroidal anti-inflammatory pain medication, local physical therapy, acupuncture, and topical pain relief creams to help relieve symptoms quickly and shorten the course of the disease. In addition, patients should pay attention to reduce lumbar activities in daily life, avoid prolonged standing, prolonged sitting, bending and weight-bearing, and can wear a lumbar brace for protection.