After a sprain of the wrist a rotation with a clicking sound may be caused by tissue friction caused by physiological phenomena, may also be caused by sprain of the wrist soft tissue damage or sprain induced tenosynovitis caused. 1. Physiological phenomenon: as the wrist in the rotation of the articular cartilage and synovial membrane will be friction, so may be issued by the clicking sound, generally is a normal phenomenon, without special treatment. 2. Pathological factors (1) Soft tissue injury: when the wrist is sprained, it may cause dysfunction of the bone, articular cartilage and surrounding soft tissues of the wrist joint. Therefore, when the wrist joint moves, the injured tissues rub against each other, and the patient can hear a clicking sound with pain. (2) Tendovaginitis: As tendons tend to rub against each other when they pass through bone elevations and joints, tendovaginitis is easily induced by sprains of the wrist, as the tissues are relatively fragile at this time. After tendovaginitis occurs, the wrist area will usually be edematous, and when rotating the wrist, the tendon sheath will rub against the edematous tendon and produce a loud sound. After a sprained wrist a rotating clicking sound of different reasons, we recommend that patients go to the hospital in a timely manner to check, clear the specific cause of the disease, and then follow the doctor’s instructions for treatment.