The presence of 10^8 IU/ml of hepatitis B virus usually indicates an extremely high viral load of hepatitis B virus and a very low chance of self-healing, except in acute infections. Hepatitis B virus level is related to prognosis, and high viral load is a high risk factor for developing cirrhosis and liver cancer. Therefore, even if there is a chance of spontaneous healing, we should not wait and should give active treatment. As long as the conditions for antiviral treatment are met, antiviral treatment should be carried out as soon as possible. Currently, you can choose interferon, entecavir or tenofovir for antiviral treatment. The antiviral treatment for hepatitis B is relatively long and should not be stopped without authorization, as unauthorized stopping of the medication will pose a risk of drug resistance.