Nephrotic syndrome relapse after stopping hormone, need to clarify the diagnosis, correct the causative factors (such as anti-infection, anticoagulation, etc., such as amoxicillin, low molecular heparin), immunosuppression (hormone, immunosuppressant, such as prednisone acetate, cyclophosphamide), etc., and improve the renal puncture biopsy to clarify the diagnosis, if necessary. 1. Definitive diagnosis: In order to avoid misdiagnosis, patients need to receive plasma protein test, lipid test and urine routine test to define the diagnosis. 2. Correcting triggers: the common reasons for relapse of nephrotic syndrome include irregular medication, combined infection, combined thrombosis, etc. Firstly, it is necessary to clarify the triggers of relapse, and then carry out targeted treatment according to related problems, such as standardizing medication (adjusting hormone dosage according to doctor’s instructions), anti-infection (amoxicillin, etc.), anti-coagulant (low molecular heparin, etc.). 3. Immunosuppression: first of all, it is necessary to clarify whether it is simply a relapse, or frequent relapses. If it is the first relapse, hormone (prednisone acetate) treatment can be turned on again; if it is a frequent relapse, it is necessary to comply with the medical advice of combined immunosuppression (cyclophosphamide, etc.), and if necessary, feasible renal puncture biopsy, to clarify the type of pathology, and guide the treatment. The application of the above drugs have a certain risk of taking, it is recommended that patients need to take under the guidance of a specialist. Patients with nephrotic syndrome are advised to consult regular hospitals in a timely manner and standardize the use of drugs under the guidance of physicians.