Urine leukocyte esterase two plus sign indicates that there is a urinary tract infection, and its treatment is mainly divided into two aspects, general treatment, anti-infection treatment. 1. General treatment. Keep local clean, pay attention to the hygiene of the perineum, drink more water to increase the flushing effect of urine, avoid eating spicy stimulating food, reduce local congestion, promote the recovery of inflammation. 2. Anti-infection treatment. According to the results of urine pathogen culture, different pathogens should be treated with appropriate anti-infective therapy. Such as bacterial infections should be treated with antibiotics such as levofloxacin; fungal infections should be treated with antifungal drugs such as fluconazole; and tuberculosis infections should be treated with regular anti-tuberculosis treatment (such as the application of isoniazid and other drugs). If urine leukocyte esterase positivity 2+ occurs, patients are advised to go to the hospital for consultation and treatment under the guidance of a doctor. Drugs should be applied under the guidance of a doctor.