The presence of H. pylori in the gastric mucosa leads to gastritis, gastric ulcers and other diseases, and long-term gastritis leads to atrophy and intestinal hyperplasia of the gastric mucosa, and gastric cancer through the heterogeneous proliferation pathway. Triple therapy means taking three drugs together to eradicate H. pylori. Currently, the eradication rate of previous triple therapy is significantly reduced due to the prevalence of drug resistance of H. pylori, so the latest expert consensus advocates that quadruple therapy is preferred for antimicrobial treatment to avoid failure of eradication in one treatment and difficulties in future antimicrobial treatment when H. pylori develops drug resistance. The quadruple therapy includes a drug that inhibits gastric acid secretion, namely proton pump inhibitors, including omeprazole, esomeprazole, rabeprazole or pantoprazole, etc. These drugs can block the channel of gastric acid secretion to ensure that the gastric environment is in a low-acid state, and antibiotics can play a better anti-H. pylori role. The next is antibiotic drugs, including amoxicillin, metronidazole, clarithromycin, levofloxacin, tetracyclines, etc., choose two of them. The fourth drug is bismuth, bismuth potassium citrate, colloidal bismuth tartrate or colloidal bismuth pectin. Because the choice of antibiotics is important and requires your doctor to select targeted medications according to your condition, it is recommended that face-to-face consultations be conducted by your doctor to prescribe medications. If you take the medication for 7 to 14 days under the guidance of your doctor, you can basically kill H. pylori completely.