Postoperative chemotherapy for colon cancer refers to a kind of adjuvant treatment to eliminate residual lesions through the use of chemical drugs after surgical treatment of colon cancer. Some colon cancers may still have residual micro-metastatic lesions after surgery, in order to kill the residual cancer cells, postoperative adjuvant chemotherapy can be carried out, and the commonly used chemotherapeutic drugs in clinic are 5-fluorouracil, oxaliplatin, etc. For patients with metastatic lesions, intravenous injection of the above chemotherapeutic drugs can also be chosen. For patients with metastatic lesions, intravenous injection of the above chemotherapeutic drugs can also be chosen to prolong the survival time of patients. Since colon cancer has a certain degree of recurrence, long-term follow-up is recommended, with regular whole colonoscopy, CEA test, and CT of chest, abdomen and pelvis to clarify whether there is recurrence or metastasis. The above drugs need to be applied under the guidance of specialized physicians.