Extensive resistance of Pseudomonas aeruginosa in lung infections can be selected by combining two or more antibiotics with different pharmacologic actions and no cross-resistance. According to the sputum specimen sensitivity results and MIC value (minimum inhibitory concentration), can choose enzyme inhibitor combination class and aminoglycoside antibiotics combined use, such as the combined use of cefoperazone sulbactam sodium and amikacin treatment, but the course of treatment should not be too long, generally controlled in 7-10 days, the longest not more than 14 days, such as the course of treatment is too long can lead to the production of related antibiotic-resistant bacteria. In addition, carbapenems (such as imipenem, panipenem, etc.) and aminoglycoside preparations combined with Pseudomonas aeruginosa also have a good synergistic effect. If the effect is not good, the combined use of polymyxin can be considered. Polymyxin has a low concentration in lung tissue, and in addition to intravenous use it is recommended that it be used in combination with nebulization in order to improve the anti-infective effect of the drug in lung tissue. It is recommended that the patient seek medical attention and systematic treatment in the hospital, strengthen the blood image and infection index monitoring, the above drugs need to be used in accordance with medical advice.