A nodule on the penis may be caused by penile sclerosis, penile tumor, prepuce and glans penis, as well as foreskin scale. 1. Scleroderma of the penis: mainly on the white membrane of the cavernous body of the penis in men, fibrous plaques appear, patients will have the performance of penile curvature, and there may be painful symptoms during erection. 2. Tumors of the penis: most of them occur in the anterior end of the penis, there will be nodules when touching, or there are lumps, there may be local pressure and pain symptoms, with the development of the disease, the nodules will further increase. 3. Inflammation of the foreskin and glans: usually caused by more serious inflammation, belonging to the inflammatory nodules. 4. Circumcision: When circumcision exists in patients with phimosis, it may be manifested as nodules on the penis, mostly due to secretions produced by the prepuce glands, and the epithelium shedding after the formation of the penis, which will also be accompanied by the symptoms of odor. If you find a nodule on the penis, it is recommended to go to the urology department of the regular hospital in a timely manner, after a clear diagnosis, active treatment.