Long-acting interferon refers to polyethylene glycol interferon alpha-2b injections. How long to take the injection depends on the type of disease being treated, the severity of the disease and the effectiveness of the treatment. If treating HPV infection, go for a review in about 1 month of treatment, which may be extended to 2 months if the HPV has not turned negative. If treating hepatitis, it takes longer time, half a year to a year, during the treatment period, the viral load and quantitative hepatitis B five should be rechecked regularly, and the specific course of treatment will be decided according to the efficacy. Polyethylene glycol interferon alpha-2b injection can be used for the treatment of chronic hepatitis C, chronic hepatitis B. Generally, it can be given once in 7 days, and patients can usually continue to use the drug for 24-72 weeks, and the specific how often to play needs to be determined according to the patient’s therapeutic effect. For example, in the treatment of chronic hepatitis B, if the surface antigen decreases by more than 1 Ig IU/ml at 24 weeks of treatment, the treatment should be continued until 48 weeks. If the decrease in surface antigen is less than 1 Ig IU/ml and the decrease in HPV DNA is less than 2 Ig IU/ml at 24 weeks of treatment, it is recommended that long-acting interferon be discontinued and a nucleotide analog such as entecavir be used for treatment. For patients with enough treatment for 48 weeks, with HBV DNA down to the lower limit of detection and Hepatitis B surface antigen down to 10 IU/ml, treatment can be extended to 72 weeks or longer in pursuit of clinical cure. It is worth noting that some patients may experience adverse reactions with polyethylene glycol interferon alpha-2b injection such as palpitations (rapid heartbeat, often accompanied by panic), dyspnea, sore throat, gastritis, bleeding gums, dry eyes, rash, and memory impairment. If the adverse reactions are severe, consult your physician for advice and consider discontinuing the drug. It is recommended that Polyethylene Glycol Interferon alpha-2b Injection can be used under the guidance of a doctor, who will comprehensively determine the specific duration of the medication for the patient’s condition, therapeutic effects and adverse reactions.