Pancreatic wall thickening is an uneven thickness of the pancreatic wall, which may be regular and uniform or irregular, and is usually associated with diseases such as pancreatitis, pancreatic stones, and pancreatic cancer. Pancreatitis and pancreatic stones mainly cause adverse reactions and affect the function of the pancreas, while the biggest danger of pancreatic cancer is that it can threaten the life. 1. Pancreatitis: mainly due to the obstruction of the exocrine function of the pancreas, it can be divided into acute pancreatitis and chronic pancreatitis, and acute pancreatitis can be divided into light and heavy pancreatitis. It is worth mentioning that light pancreatitis generally has a good prognosis, while heavy pancreatitis can be accompanied by multi-organ dysfunction, seriously affecting the life, and chronic pancreatitis can lead to pancreatic dysfunction and cancer. 2. Pancreatic stones: Smaller stones are generally less harmful, but if the stones gradually increase in size, they may induce pancreatitis and abdominal pain, which has a greater impact on the patient’s life. Some patients may suffer from pancreatic stones, which may affect normal eating and lead to weight loss. 3. Pancreatic cancer: it is a malignant tumor in the pancreas, which is more complicated, and if not treated in time, it will shorten the survival time of the patients, and the death rate is also higher. If only thickening of pancreatic wall is detected, it is recommended to consult the doctor as soon as possible and confirm the diagnosis of the disease through enhanced CT, pathological biopsy, tumor marker screening, etc., and then target treatment according to the diagnostic results.