Children with blisters formed around the lips and mouth are usually viral blisters, caused by colds, viral blisters can be treated according to antiviral therapy. It is recommended that oral antiviral drugs or intravenous drip antiviral drugs for treatment, at the same time can be applied externally antiviral drug treatment, to be treated by the child’s cold and fever, blisters will be cured, the treatment cycle of 7-14 days, after a systematic treatment can be cured. Children’s mouth long blisters mostly occur in the spring and fall seasons, the northern temperature and climate is relatively dry, most of the children because in the kindergarten, once there is a child because of a cold viral infection, will also make the other children to appear such a situation. Parents must pay attention to hygiene, children should wash their hands before meals, into the room after washing hands, drink more water.