Pain in the wrist from holding something heavy can be due to overwork and tendinitis. 1. Overexertion: After a long period of activity, the muscles are overworked and show symptoms of pain. At this time, you should pay attention to reduce activities, pay attention to rest, after a period of time can be relieved. 2. Tenosynovitis: If the tendon and tendon sheath will occur aseptic inflammatory reaction, which leads to edema, adhesion and other symptoms, which in turn leads to pain symptoms during activities. Considering tenosynovitis, patients can take non-steroidal anti-inflammatory drugs such as ibuprofen to relieve pain. If the patient’s wrist pain with heavy things, may also be due to cold, carpal tunnel, etc., should go to the hospital in time for examination and treatment.