Commonly used therapeutic drugs for premature ovarian failure include estrogen, progesterone, calcium and vitamin D, etc., which should be used according to doctor’s prescription. 1. Estrogen: Estradiol, estradiol valerate, etc. Generally, premature ovarian failure is caused by insufficient estrogen secretion, so additional supplementation of estrogen can alleviate the symptoms of low estrogen in patients with premature ovarian failure, such as hot flashes, excessive sweating and palpitations. 2. Progesterone: common progesterone capsules, dydrogesterone tablets, etc. Generally, progesterone needs to be used together with estrogen, which can simulate the artificial cycle to make the uterine lining proliferate and fall off, and trigger menstruation. 3. Calcium and vitamin D: For patients with decreased bone density or osteoporosis, calcium and vitamin D can be supplemented. If premature ovarian failure occurs, it is recommended to consult a regular hospital in a timely manner, complete the relevant examinations, and follow the doctor’s instructions to standardize the use of medication.