Hyperhomocysteinemia is recommended to be treated with 0.8mg per day, and co-supplementation with vitamins, etc. is recommended, with attention to adverse effects and contraindications. Hyperhomocysteinemia can be intervened with folic acid, but folic acid alone may be ineffective, and is usually used in combination with several medications. The recommended daily intake of folic acid is 0.8 mg per day, unless otherwise prescribed, and excessive folic acid intake may lead to increased adverse effects and zinc deficiency. Concurrent supplementation with vitamin B12 and other medications is also recommended. When using folic acid, it is recommended to temporarily stop using the medication and consult a doctor if there are signs of adverse reactions such as loss of appetite, nausea and vomiting, abdominal discomfort, or deepening of the color of the urine. In case of drug allergy, vitamin B12 deficiency, megaloblastic anemia, etc., the use of the drug is prohibited. Hyperhomocysteinemia is recommended to go to the hospital; the drug needs to be used under the guidance of clinicians.