The severity of premature ovarian failure can be determined by the hormone levels in the body as well as by imaging and daily performance. If it is found that the estrogen level in the body is obviously reduced, the blood luteinizing hormone and follicle stimulating hormone are obviously elevated, or if it is found that the volume of the ovary is obviously reduced by ultrasonography, in which there is no follicle, it is mostly suggestive that premature ovarian failure is more serious. If a woman has irregular menstruation or even amenorrhea, long-term insomnia that affects her daily work and life, is often easily agitated and can’t control herself easily, has dry skin, chloasma, long-term fatigue, bone and joint pain, and loss of libido, it is more likely to suggest that premature ovarian failure is more serious. If the patient has premature ovarian failure, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor, improve the relevant examination, to clarify the cause of the disease, and target treatment.