The blister-like pimples on the face are considered to be chickenpox, herpes simplex, herpes zoster, eczema and so on. 1. Chickenpox: chickenpox is caused by varicella zoster virus, the patient’s typical symptoms of erythematous macular rash, papules, herpes, easily accompanied by fever, cough and asthma and other symptoms, so some of the patients can be manifested as blisters on the face of the same acne. 2. Herpes simplex: Herpes simplex is caused by infection with the herpes simplex virus, and it is triggered by fatigue and low immunity. The disease can cause burning sensation on the skin and mucous membranes of the patient, clustered blisters and loss of appetite, fever, localized lymph node enlargement and other symptoms, can also be manifested as blistering pimples on the face. 3. Herpes zoster: herpes zoster is caused by varicella zoster virus, which can cause blistering acne on the face of some patients. Some patients may also experience other symptoms such as burning or tenderness of the affected skin, mild fatigue, low-grade fever, and loss of appetite. 4. Eczema: the cause of eczema is not clear, may be related to abnormal immune function, exposure to allergic substances. Eczema will cause the patient’s skin to appear erythema, edema, corn size papules, blisters, flaking and other symptoms, and the lesions will be vesicles, oozing, and some patients may be manifested as blisters on the face of the same acne. It is recommended that people with blistering acne should consult a doctor for examination and treatment after clarifying the cause of the disease. Pay attention to daily skin care, avoid foreign body friction stimulation.