Autoimmune hepatitis needs to be diagnosed by questioning, diagnostic score system, and relevant tests, but there is no clear data on its relevant differential diagnosis. 1.Diagnosis: (1) Questioning: Usually when a patient visits a doctor, the doctor will first question him/her to understand the patient’s condition, which mainly includes how long the digestive symptoms have been present, history of autoimmune diseases, family history, whether he/she has been vaccinated against hepatitis viruses and whether he/she has taken any special medications recently, and so on. (2) Diagnostic score system: The items in the diagnostic score system mainly include the results of autoimmune antibodies in the blood and the histopathological results of liver puncture for comprehensive scoring. (3) Relevant examinations: Usually, patients need to undergo physical examination, laboratory examination, imaging examination and special examination. General physical examination is mainly to observe whether the patient has jaundice, limb edema, petechiae, hepatosplenomegaly, liver pressure and spleen tenderness, etc., while laboratory examination may show elevated alanine aminotransferase and aspartate aminotransferase, elevated Y-globulin. 2. Differential diagnosis: autoimmune hepatitis is easily confused with other types of hepatitis because of the similarity of symptoms. Usually, patients with mild disease may not have any symptoms, but if patients have symptoms of liver function impairment such as abdominal distension, fatigue, anorexia, etc., or even accompanied by other organs or systemic immune diseases, or with unexplained aminotransferase elevation, we need to raise the vigilance in time. It is recommended that the patient actively cooperate with the doctor to carry out relevant examinations for diagnosis, and if the diagnosis is clearly made as autoimmune hepatitis, active treatment is also required.