Autoimmune hepatitis is a disease that needs to be considered in any patient with acute or chronic hepatitis. Its onset is relatively rare and inherently heterogeneous, and many clinicians and patients are not sufficiently aware of it or are unable to diagnose and treat it correctly, resulting in many patients being underdiagnosed, not receiving effective treatment, or receiving irregular treatment, or irregularly discontinuing medications due to concerns about associated hormones and other side effects, and lack of effective side effect monitoring, resulting in ineffective control of the disease, leading to cirrhosis, liver failure, and the occurrence of liver cancer. In fact, there are clear, mature and effective treatment options for this disease, provided that all we need to do is to have a full and comprehensive understanding of the disease. On September 1, 2015, the European Organization of Hepatology published guidelines for the diagnosis and treatment of autoimmune hepatitis. The guidelines provide a comprehensive overview of the epidemiology, history, clinical features and manifestations, staging, relationship with primary biliary cirrhosis (and diseases such as primary sclerosing cholangitis and drug-related hepatitis), diagnostic criteria and various details, treatment principles and various details, how to monitor the disease, how to discontinue medications, how to deal with special populations such as children, pregnant women, and elderly people, in 34 pages with 347 references. It is the most comprehensive, up-to-date and authoritative diagnosis and treatment guide that I know of to date, and it is a must-read article for every doctor or patient involved in liver disease.