High thyroglobulin may be caused by autoimmune thyroiditis, which may have no clinical symptoms in the early stage, and the clinical manifestations of goiter, such as dyspnea, hoarseness, and hypothyroidism in the late stage. 1. Difficulty in breathing: If the situation of high thyroglobulin is more serious, with the development of the disease, it may compress one or both sides of the trachea, resulting in dyspnea, and in severe cases, patients may also suffer from asphyxiation. 2. Hoarseness: After suffering from high thyroglobulin, the large veins in the deep neck may be compressed, leading to obstruction of venous return in the head, and the superficial veins in the neck and chest may be significantly expanded, resulting in hoarseness of the patient’s voice, which may be accompanied by facial bluish coloration. 3. Symptoms of hypothyroidism: When patients have symptoms of hypothyroidism, they may have mental symptoms such as memory loss, dizziness, tinnitus, fatigue, anorexia, muscle weakness, bradycardia and other symptoms. In addition, high thyroglobulin can also be seen in thyroid cancer, hyperthyroidism, etc. It is recommended that patients with high thyroglobulin should consult a doctor in time and cooperate with the doctor for treatment.