Thrombocytopenic purpura caused by immune system disorders, such as systemic lupus erythematosus, desiccation syndrome, and other underlying diseases, the main thing is to control the progression of the primary disease as soon as possible. Treatment options mainly include glucocorticoids, immunoglobulin, splenectomy, immunosuppressants, etc. Platelet transfusion is necessary to reduce the risk of bleeding. 1. Glucocorticoid: glucocorticoid volume therapy is the preferred treatment option, such as prednisone acetate tablets. 2. If there are contraindications to hormones, immunoglobulin infusion can be considered to boost platelet count. 3. Splenectomy: If there is a combination of hypersplenism, splenectomy can be considered. 4. Immunosuppressant, CD20 monoclonal antibody: If the above treatments are unsatisfactory, immunosuppressant such as cyclosporine, vincristine, etc. and CD20 monoclonal antibody such as rituximab can be considered. If the patient has current thrombocytopenic purpura with bleeding tendency, platelet transfusion can be given to reduce the risk of bleeding. Purpura caused by immune disorders requires long-term, regular treatment under the supervision of a rheumatologist.