Pain at the root of the right palm thumb may be due to soft tissue injury, joint dislocation or tendinitis. 1. Soft tissue injury: patients who have soft tissue injury to the muscles at the root of the thumb due to trauma or chronic strain injury may experience pain at the root of the right palm thumb. 2. Joint dislocation: if the metacarpophalangeal joint at the root of the thumb is dislocated or subluxated due to trauma, the pain at the root of the right palm thumb may occur. 3. Tendovaginitis: if the patient has tendovaginitis due to chronic strain injury or congenital tendon abnormality, when the tendon sheath is edematous and thickened, the tendon will be pressed, which may lead to pain at the root of the right palm thumb. When the patient has pain at the root of the right palm thumb, he should consult a doctor in time and carry out examination and treatment under the doctor’s guidance, which is conducive to the early improvement of pain and discomfort.