Gammaglobulin is an immunoglobulin product extracted from human plasma, which has the effect of treating infectious and immune diseases, and is generally not used for the treatment of edema, and there is no clear efficacy in its treatment of edema. The common clinical preparation for edema is human albumin injection, which can increase the colloid osmotic pressure in the blood, and it is effective for edema caused by hypoproteinemia or hypotonic state, while it is not suitable for edema caused by other reasons. For dystrophic edema, most of them have a history of malnutrition, edema can involve the whole body, and wasting in the absence of edema is its characteristic. Treatment is mainly based on supplemental nutrition, and intravenous infusion of albumin can improve to a certain extent. However, for cardiogenic edema, renal edema, hepatic edema, etc., it is necessary to target the treatment of the primary disease, to remove the triggers that cause edema, and if necessary, can be taken in the form of extracorporeal drainage to ease the condition. Edema transfusion of gammaglobulin may be to improve the patient’s immunity and prevent certain infectious diseases. It may be used in combination with antibiotics in the treatment of some serious infectious diseases. Drug use should be under the supervision of a physician.