Women who take estradiol do not appear to gain weight, but normal adult women do not need additional estradiol supplementation. Estradiol is an estrogenic drug that can be used for various causes of estrogen deficiency symptoms, such as dizziness, hot flashes, sweating, sleep disorders, genital atrophy, vaginal dryness, and atrophic vaginitis, but normal adult women do not need additional estradiol supplementation. For most women, regular use of estradiol medication as prescribed by the doctor will not cause women to experience symptoms of weight gain. However, it should be noted that some women feel weight gain after taking estradiol, mainly because estrogen may have a water-sodium retention effect, and the weight gained is the water component, and the water can be discharged after stopping the drug, and the weight can return to normal. Women should follow the doctor’s instructions to use the drug, allergic to the components of the product is prohibited; the use of a cycle of ineffective people to stop; pregnancy and lactation women are prohibited to use this product.