Approximately 60-70% of patients with epilepsy are seizure-free after antiepileptic drug therapy. Usually, patients with epilepsy who have been seizure-free for more than 2 years have the possibility of tapering off their medication. The risk of recurrence should be carefully evaluated, and when the risk of recurrence is low, and the risk/benefit ratio of medication reduction to continued medication is fully communicated with the patient or guardian, a gradual withdrawal of antiepileptic medication may be considered. The EEG has a reference value for the withdrawal of antiepileptic drugs. The EEG should be reviewed before the drug is reduced and preferably again before discontinuation. In most epileptic syndromes, the EEG should be completely free of epileptiform discharges before considering the reduction of medication. A few age-related epilepsy syndromes (e.g., BECT) that are older than the age of the disease do not exactly require a normal EEG before withdrawal. Those with structural brain abnormalities or some specific syndromes (e.g. JME, etc.) should be extended to 3-5 years seizure-free. In the case of monotherapy, the withdrawal process should take at least 6 months; in the case of polypharmacy, the withdrawal time of each antiepileptic drug should be at least 3 months, and only one drug should be withdrawn at a time. 4. In the case of withdrawal of benzodiazepines and barbiturates, the withdrawal time should not be less than 6 months for possible withdrawal-related syndromes and/or recurrence of seizures. 5. If seizures recur during withdrawal, the medication should be returned to the dose before the reduction and medical advice should be given. 6. If seizures recur within a short period of time after discontinuation, previous medication should be resumed and followed up; seizures with triggers after 1 year of discontinuation can be observed, attention should be paid to avoid triggering factors, and antiepileptic drugs can be withheld; if there are more than 2 seizures per year, the treatment plan should be evaluated again.