Hashimoto’s thyroiditis with nodules, if the size of benign thyroid nodules is small, the patient does not have obvious discomfort symptoms, the thyroid function is normal, may not take treatment, regular review can be. If the nodule is malignant or has pressure symptoms, it should be removed by surgery. Patients with abnormal thyroid function can be treated with medication. Patients with Hashimoto’s thyroiditis and benign thyroid nodules do not need treatment if they have no symptoms, and regular follow-up observation is sufficient. Patients with obvious compression symptoms or malignant nodules need thyroid surgery. For patients with hypothyroidism, hormone replacement therapy is needed, and levothyroxine sodium tablets are commonly used in the clinic, and thyroid function needs to be rechecked regularly. Hashimoto’s hyperthyroidism is mostly transient, the degree is usually mild, so patients in the hyperthyroidism period is generally not the use of anti-thyroid medication, can be used to alleviate the symptoms of hyperthyroidism such as palpitations, hand tremors, sweating and so on β-blocker drugs. The above medicines are for reference only, the specific dosage and usage should follow the doctor’s instructions. When Hashimoto’s thyroiditis with nodules occurs, seek prompt medical attention and follow the doctor’s instructions.