The main reason for urethral spasm in prostatitis is caused by inflammation stimulating the urethral mucosa, smooth muscle and nerves, which needs to be actively treated to control inflammation and improve symptoms. Under the persistent stimulation of inflammation, it will cause damage to the urethral mucosa, which in turn will cause irritation of the urethral smooth muscle and nerves, resulting in uncontrolled contraction of the urethra, which is manifested as urethral spasm. When prostate inflammation occurs, patients are advised to take antibiotics such as doxycycline, ceftriaxone, azithromycin and other drugs to control inflammation, and also tamsulosin, tolterodine and other drugs to relieve spasm. Due to individual differences, the drug does not have the absolute most effective and safest, it is recommended to standardize the use under the guidance of a doctor, the emergence of adverse reactions recommended to consult a doctor, drug allergy is prohibited. Through standardized treatment, it can significantly relieve the patient’s discomfort and improve the prognosis of the disease.