Soreness of ankle joints after walking for a long time is mainly due to chronic strain injury, resulting in local soft tissue congestion, edema, inflammation, and corresponding damage to bone under high load, including wear and tear of cartilage, bone extrusion, etc. Local aseptic inflammation restricts blood circulation, which also aggravates the symptoms of soreness. This situation should be braked and rested to promote the recovery of local blood circulation, and hot compresses can be applied as well as topical medications to activate blood circulation, eliminate blood stasis, reduce swelling and relieve pain, commonly used are Futalin emulsion and Chinese medicine Jinhuang cream. If the symptoms are serious, oral medication can be used to assist the treatment, including Fenpropidol and Celecoxib, and Chinese patent medicines, such as Jinlong Pills and Tongluo Kaipao Tablets, can be used to alleviate the poor local blood circulation. After rest as well as medication, the symptoms can be significantly relieved in about a week. If the symptoms are not relieved and the symptoms flare up frequently, it is important to go to the hospital for examination to see if there is any change in the bone quality of the ankle joint.