Indications for methylprednisolone shock in lupus nephritis: 4 common indications. ① Lupus cerebri Do not wait for a seizure before diagnosing lupus cerebri, it is too late; if the patient presents with severe dizziness, headache or disorientation, as in a patient who, after eating, asks her, “Did you eat? but answers, “No, no. This is disorientation; or abnormal changes in mood, or even mental confusion, to identify whether it is from taking hormones or lupus brain. All these may be early manifestations of lupus brain. The first discoverer of lupus brain is often not the medical staff but the family members who stay with the patient. Lumbar puncture can be done to determine the cerebrospinal fluid, and some patients will have increased pressure and elevated protein; however, some cerebrospinal fluid may also be normal, and the diagnosis is difficult, and treatment can be tried. Lupus nephritis with acute deterioration of kidney function is certainly type IV, with or without crescent, large crescent or small crescent may be possible, and whether lupus type IV is crescentic nephritis is possible. It is common to see acute deterioration of kidney function with or without crescent formation, and this treatment is very effective. In some cases of lupus nephritis with poor renal function, it is not advisable to give up, but to actively treat, or even intensify, dialysis while intensifying treatment, so that many patients can get rid of dialysis and even restore normal renal function. Of course, this situation is suitable for type Ⅳ, type VI can not, and the vast majority of poor renal function is Ⅳ. (3) Hematologic crisis Significant decrease in platelets and blood transfusion or severe anemia, hematocrit down to 3g to 5g, or cardiac dysfunction. ④Severe myocardial damage Various severe arrhythmias or intractable heart failure.