In the treatment of lupus nephritis, the use of immunosuppressants is certainly important, but focusing only on the treatment of lupus while neglecting the protection of renal function ultimately results in the failure of treatment. In fact, if the kidney damage caused by lupus activity is serious, even if the lupus is not active, the kidney lesions can continue to worsen and develop nephrosclerosis, leading to renal insufficiency. Therefore, during the treatment of lupus nephritis, attention must be paid to the protection of renal function to avoid renal insufficiency. Some patients may already have different degrees of renal insufficiency at the time of consultation due to repeated activities of lupus or delayed treatment, and they should also try to delay the development of renal damage. To protect kidney function, we should first understand what factors can aggravate kidney function damage? 1, hypertension Lupus nephritis is often complicated by hypertension, and hypertension is the biggest risk factor for kidney function deterioration, so patients with lupus nephritis must pay attention to the presence of elevated blood pressure, and if there is high blood pressure must be strictly controlled. 2, proteinuria Proteinuria not only reflects glomerular damage, but also can cause glomerular interstitial damage, leading to the progression of kidney disease, therefore, reduce proteinuria, delay the progression of kidney disease, can play a role in protecting kidney function. 3, nephrotoxic drugs Many drugs have damage to the kidney, such as sulfonamides, aminoglycoside antibiotics (kanamycin, gentamicin, etc.), polymyxin B and other antibiotics; traditional Chinese medicine (especially Guanmutong, Fangqi, etc.); antipyretic and analgesic drugs; heavy metal drugs (penicillamine, etc.). Try to avoid using such drugs to avoid aggravating kidney damage. 4. Infections During the treatment of lupus nephritis (especially during the initial months of induction therapy), infections, including bacteria, viruses, fungi, protozoa, etc., are likely to occur. Infection often leads to recurrence or aggravation of the disease, therefore, attention should be paid to prevention in daily life and avoid going to crowded places to reduce the occurrence of infection. Once the infection occurs, should promptly seek medical consultation. 5, obesity obesity is currently a major problem within the global harm to public health, obesity is not only hyperlipidemia, hypertension, coronary heart disease risk factors, but also can increase proteinuria, aggravate kidney damage. Of course, there are other factors, such as cardiac insufficiency, acidosis, electrolyte disorders, hyperlipidemia, etc., which should be corrected in the treatment process.