A large pustule on the head is mostly caused by bacterial infection, which can be treated by general treatment, medication, surgery and other measures. 1. General treatment: first of all, you should keep the skin clean and hygienic, do not squeeze the pustule, avoid scratching and stimulation, choose a light diet, soft, easy to absorb and digest the ingredients, eat less chili peppers, quit smoking and drinking, live a regular life, go to bed early and get up early, avoid staying up all night and exertion. 2. Medication: You can disinfect the pustules and the surrounding skin with iodophor, and use antibiotic medication such as erythromycin ointment and fusidic acid cream externally to treat the pustules. 3. Surgery: If the symptoms cannot be relieved by the above measures, or if the disease worsens and fluctuates, the pus secretion can be discharged through surgical incision and drainage. If you have a large pustule on your head, it is recommended that you go to the hospital in time for examination and treatment as prescribed by the doctor.