Newborns are immunized with BCG and Hepatitis B vaccines. The appearance of pus after BCG vaccination is normal, while the appearance of pus after Hepatitis B vaccination requires active anti-infective treatment. Newborns need to be vaccinated with BCG vaccine after birth to prevent their bodies from being infected with Mycobacterium tuberculosis and thus prevent the occurrence of tuberculosis. Hepatitis B vaccine is the first vaccination after birth, which can be used to prevent the infection of hepatitis B virus and thus prevent the occurrence of hepatitis B. The vaccination site of BCG vaccine can be used to prevent the infection of hepatitis B virus. It is normal for pus to appear at the site of BCG vaccination, usually no special treatment is needed, and it is enough to keep the area clean and hygienic. If pus appears at the vaccination site after vaccination with hepatitis B, the possibility of infection cannot be ruled out, and it is recommended to clean and disinfect the area in time, and antibiotics can be taken under the guidance of the doctor for anti-infection treatment, such as roxithromycin and so on.