The National Polyp Study Program (NPS) found that patients often avoid the risk of colorectal cancer with colonoscopic polypectomy. Ann G. Zauber, MD, PhD, of the New York Center for Epidemiology and Biostatistical Medicine and Kettering Cancer Center, et al. examined changes in patient mortality over time after performing colonoscopic polypectomy on patients with colorectal cancer. The relevant findings were published in the prestigious international journal NEJM 2012, issue 8. All patients with polyps (adenomatous or non-adenomatous) undergoing colonoscopy at NPS clinical centers from 1980 to 1990 were included in the study as a sample for analysis. National mortality parameters were used to determine the number of patients who died and the cause of death; follow-up was up to 23 years. The mortality rate of colorectal cancer patients after colonoscopic adenomatous polyp resection was compared with the expected mortality rate of colorectal cancer in the general population, and the results were obtained by the supervised epidemiology, end result (SEER) procedure, and the observed mortality rate of colorectal cancer patients with non-adenomatous polyps (as an internal reference) statistics. The 2602 patients who underwent adenomatous polyp resection included in the study had a total of 1246 deaths from all causes during a median follow-up period of 15.8 years, 12 of which were due to colorectal cancer. The standardized mortality ratio for patients who underwent colonoscopic polypectomy was 0.47 (95% confidence interval [CI], 0.26 to 0.80), suggesting a 53% reduction in mortality, compared with 25.4 expected deaths in the general population with colorectal cancer over the same period. Mortality rates were similar for patients with adenomatous and nonadenomatous colorectal cancer 10 years after polypectomy (relative risk, 1.2; 95% CI, 0.1 to 10.6).