Itchy in the middle of the night may be caused by environmental factors, atopic dermatitis, scabies and other reasons. 1. Environmental factors: Sleeping at night in a cold and dry environment, the skin is prone to become dry and flaky, making the skin nerve endings exposed, and when the environment is stimulated in the middle of the night, causing itching. 2. Allergic dermatitis: it may also be in contact with allergens, such as sleeping at night covered bedding or sheets, are likely to stimulate the allergy caused by itching symptoms. 3. Scabies: a contact infectious skin disease caused by scabies parasites in the epidermis of human skin, this disease will be accompanied by intense night itching. For patients who itch in the middle of the night, attention should be paid to maintaining a clean and comfortable sleeping environment. If the long-term unexplained itching in the middle of the night, you should go to the regular hospital in a timely manner to clarify the cause of the disease, under the guidance of the doctor targeted treatment.