All long-acting antihypertensive drugs have certain side effects, so there is no such thing as which long-acting antihypertensive drug is better without side effects. Generally long-acting antihypertensive drugs include bisoprolol, irbesartan, nifedipine controlled-release tablets, metoprolol and so on. Although, there are many kinds of long-acting antihypertensive drugs, but basically all have certain side effects, therefore, there is no long-acting antihypertensive drugs which is good without side effects. Usually, for patients with high blood pressure, long acting antihypertensive drugs such as Bisoprolol, Irbesartan, Nifedipine Controlled-Release Tablets, Metoprolol, etc. can be applied under the guidance of doctors. Generally speaking, the side effects of Bisoprolol and Irbesartan are relatively small, although patients may experience slight fatigue, dizziness, headache and other symptoms after taking Bisoprolol, but they usually subside naturally in 1 to 2 weeks after the drug is used; Irbesartan has fewer common adverse reactions, such as dizziness, flushing and so on, which will not cause too much impact on the body’s health either! While nifedipine controlled-release tablets and metoprolol can cause different degrees of adverse reactions to a number of human systems, commonly found in the cardiovascular system, circulatory system, respiratory system and so on. To summarize, patients need to take long-acting antihypertensive drugs with fewer side effects under the guidance of a doctor, and should not use drugs on their own to avoid delaying their condition.