Patients with stage 4 renal failure should be treated with medication according to their condition, and emergency dialysis and kidney transplantation if necessary. 1. Drug therapy: patients with renal failure stage 4 usually have decreased urine output, edema, accompanied by anemia, calcium and phosphorus disorders, acidosis, etc. Sodium diuresis can be carried out to reduce the volume load, such as furosemide, torasemide, etc., to correct the anemia (e.g., rosacestat, polysaccharide iron), to correct calcium and phosphorus disorders (e.g., calcium acetate, lanthanum carbonate), and to correct the acidosis (e.g., sodium bicarbonate) and so on. 2. Dialysis treatment: Kidney failure stage 4 is the most serious uremia stage, at this time, the kidney function has basically completely failed, acidosis and water-electrolyte balance disorders are prone to occur, and other organs of the body are easily affected, such as combined with heart failure, pericardial effusion, pulmonary edema and so on. At this time, hemodialysis or peritoneal dialysis is needed. 3. Kidney transplantation: patients with stage 4 kidney failure can achieve the goal of completely improving kidney function through kidney transplantation. Patients with stage 4 kidney failure should go to the nephrology department of regular hospitals in time and take targeted treatment under the guidance of professional doctors. Follow the doctor’s prescription and avoid blind medication.