Granular sputum is not specific and may be caused by respiratory tract infections caused by bacteria, viruses, mycoplasma, chlamydia, etc., including laryngitis, bronchitis or pneumonia and other respiratory tract diseases. 1, pharyngolaryngitis: when the mucous membrane of the patient’s throat is infected by pathogens, there will be congestion and edema of the throat, sputum becomes viscous and clumped to form granular sputum, accompanied by coughing, dry throat and other symptoms. At this time, through the laryngoscope to understand the situation of the throat, and check the blood routine to determine whether the laryngitis is caused by bacterial infection or viral infection, in order to treat the symptoms. 2, bronchitis: when the patient’s bronchial infection, airway secretion will increase, over time will make the secretion sticky and crusted with granular sputum, sputum culture can be carried out at this time to understand what pathogens caused by bronchial inflammation, and then for treatment. 3、Pneumonia: when pathogenic microbial infection, so that the alveoli and interstitial lung inflammation, there will be a cough or cough sputum, sputum more mucous or even granular, sometimes accompanied by chills, high fever, dyspnea and other symptoms, this time must be through the patient’s past history, symptoms and signs of the manifestations of the specific nature of the pneumonia, and then the relevant treatment. When granular sputum appears, it is recommended to consult a specialist in time to further clarify the cause of the disease and target treatment.