Spironolactone is a potassium-preserving diuretic, but the diuretic effect is weak. Both men and women should not take spironolactone without its indications, as it will not only be of no benefit to the body, but also cause a series of adverse reactions. Spironolactone is suitable for primary aldosteronism and edema caused by heart failure, cirrhosis ascites, nephrotic syndrome and other diseases, secondary aldosteronism, with a more moderate diuretic effect, while helping to improve cardiac function, lower blood pressure, but also as an adjuvant drug for the treatment of hypertension. Patients who do not have the above indications or whose doctors have not clearly prescribed spironolactone should not take it at will. Taking spironolactone often causes gastrointestinal reactions such as nausea, vomiting, diarrhea, as well as headache, dizziness, drowsiness, and hives. Since spironolactone is a potassium-protective diuretic, unauthorized use may also induce hyperkalemia. In addition, unauthorized use by women may cause estrogen abnormalities, resulting in adverse symptoms such as breast swelling and pain, increased hairiness, menstrual disorders, decreased libido, and thickened tone. Therefore, patients should avoid taking medication at random, and even if they take it under the guidance of a doctor, they need to take it on time and in the right amount, and should not change the dosage at will.