The causes of glomerular filtration rate decrease include acute factors and chronic factors, in which the glomerular filtration rate of those caused by acute factors can generally be rebounded, while the glomerular filtration rate of those caused by chronic factors can generally not be rebounded despite standardized treatment. Clinically, the diseases that cause glomerular filtration rate to decrease are categorized into acute factors and chronic factors. Among them, acute factors such as dehydration, heart failure, urinary tract obstruction and other causes, after correcting the cause of the disease, glomerular filtration rate can mostly recover by itself. Chronic factors caused by glomerular filtration rate decline although actively treated, generally can not be rebounded, chronic factors caused by glomerular filtration rate decline, common diseases are glomerulonephritis, nephrotic syndrome, diabetic nephropathy and so on. In terms of treatment, early stage of the disease requires strict control of blood pressure, blood glucose, uric acid, urinary protein and other indicators, and if necessary, renal puncture biopsy is required to assist in diagnosis and treatment. Patients with abnormal glomerular filtration rate are recommended to visit regular hospitals and receive standardized treatment under the guidance of physicians.