Duodenal bulb ulcers that do not heal for a long time may be caused by improper medication, uncontrolled diet and so on. General treatment, drug treatment, surgical treatment and other ways of treatment, drugs such as omeprazole, magnesium aluminum carbonate. 1. General treatment: combine work and rest, pay attention to rest, quit smoking and drinking, avoid overfeeding or overfeeding, avoid eating stimulating food. Develop good eating habits, small meals, regular meals, regular meals. Overfeeding will stimulate the secretion of gastrin, so that excessive secretion of gastric acid, while eating too little gastric acid can not be fully neutralized, stimulating the ulcer, causing severe pain. 2. drug treatment: duodenal bulb ulcer pathogen is mainly Helicobacter pylori, the first should be eradicated this bacterium, the method is: proton pump inhibitors, bismuth, with two kinds of bactericidal drugs of the quadruple therapy adherence to two weeks, such as omeprazole, bismuth potassium citrate, amoxicillin, clarithromycin. 3. Discontinuation of drugs for mucosal damage: e.g. non-steroidal anti-inflammatory drugs. 4. Surgery: Surgery is needed if there is no relief or even further aggravation of symptoms after medication, or if there are other complications such as gastrointestinal bleeding, perforated ulcers, or scarred pyloric obstruction. If the duodenal bulb ulcer is not cured, it is recommended to consult a doctor in time and give symptomatic treatment after the cause of the ulcer is clarified under the doctor’s guidance, so as to avoid delaying the condition.