Azithromycin and Cephalosporin are fully known as Azithromycin and Cephalosporin. Whether a child takes Azithromycin or Cephalosporin for a cold or flu is mainly judged according to the type of disease infection and the child’s allergy to the drug. However, this type of judgment has a strong professionalism, must be carried out by the doctor, the use of medication should first consult the doctor, and in the guardian’s help to use. 1. Disease infection type: azithromycin and cephalosporin have different antibacterial spectrums. Azithromycin is commonly used in the clinic for infections caused by sensitive bacteria, especially for mycoplasma infections, including bronchitis, pneumonia, skin and soft tissue infections, otitis media, sinusitis, pharyngitis, tonsillitis and so on. Cephalosporin is a broad-spectrum drug with antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, Diplococcus pneumoniae, Bacillus diphtheriae, Bacillus pneumoniae, Proteus mirabilis, and Bacillus influenzae. Clinically, it is commonly used in serious infections caused by drug-resistant golden staphylococcus and gram-negative bacilli, such as lung infections, urinary tract infections, sepsis, meningitis, endocarditis and so on. 2. Drug allergy: children who are allergic to cephalosporins can choose azithromycin, on the contrary, children who are allergic to azithromycin can choose cephalosporins. If there is a need to use azithromycin and cephalosporin children, please in the guardian’s help in accordance with the doctor’s instructions to use the drug, do not be arbitrary use.