Syphilis negative can mean that the body is not infected with syphilis this kind of disease, if it is in the incubation period may not be detected. Syphilis is a sexually transmitted disease, the main pathogen is the syphilis spirochete, mainly through sexual contact, mother-to-child transmission, blood transmission, the incubation period of about 10 days to three months, if high-risk sex three months after the examination of negative syphilis can basically rule out the infection of syphilis; if the examination of the three months of negative can not be ruled out, but also should be regular review of the corresponding. Syphilis is harmful, will violate the whole body tissues and organs, there is a high risk of contact, should be early detection, early treatment, if the diagnosis of syphilis infection, generally need to follow the doctor’s advice to choose penicillin drugs for treatment, such as Procaine penicillin B, benzylpenicillin and so on. It is recommended that patients consult a doctor for a clear diagnosis in a timely manner, and the application of drugs needs to strictly follow the doctor’s instructions.